Molina JM, Casin I, Hausfater P, Giretti E, Welker Y, Decazes JM, Garrait V, Lagrange P, Modai J; National Conference on Human Retroviruses and Related Infections.
Program Abstr Second Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 2nd 1995 Wash DC. 1995 Jan 29-Feb 2; 77.
Infectious Disease Department and the Laboratory of Microbiology, Saint Louis Hospital, Paris, France.
All HIV-infected patients with Campylobacter infection identified by the laboratory of microbiology between July 1989 and April 1994 were studied, and their clinical features as well as their response to therapy recorded. Campylobacter infection was documented in 38 patients. Campylobacter spp. was isolated from stools in 36 cases and from blood cultures in 4 cases. Species identification yielded C. jejuni in at least 90% of the cases. High-level resistance to quinolones was frequently observed (21%), but resistance to erythromycin (3%) and to tetracylines (5%) was rare. Diarrhea, fever and abdominal pain were the main clinical features of Campylobacter infection. Seventy-six per cent of the patients had AIDS, and their mean CD4 cell counts was 74 cells/microliter. Others intestinal pathogens were associated with Campyobacter in 42% of the patients. Most patients had an acute illness which rapidly resolved under appropriate antimicrobial therapy. Eight patients however (21%), experienced a chronic diarrhea with persistent isolation of Campylobacter jejuni and selection of multiple resistant strains, requiring prolonged courses of antibiotics. Four other patients (10.5%) experienced a relapse a mean of twelve months following the first episode. Campylobacter is a cause of acute enteritis in patients with HIV-infection. Because of the significant prevalence of antibiotic resistance, antimicrobial therapy should be guided upon in vitro susceptibility testing. Despite appropriate therapy however, some patients will present with a chronic course and in vivo selection of multiple resistant isolates.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Anti-Bacterial Agents
- Anti-Infective Agents
- CD4 Lymphocyte Count
- Campylobacter
- Campylobacter Infections
- Campylobacter jejuni
- Diarrhea
- Erythromycin
- HIV Infections
- HIV Seropositivity
- Health Personnel
- Humans
- In Vitro
- Prevalence
- therapy
Other ID:
UI: 102213104
From Meeting Abstracts