Tsoukas CM, Bernard NF, Sampalis J, Strawcsznsky H, Growe G, Card R, Kobrinsky N, Gold P; National Conference on Human Retroviruses and Related Infections.
Program Abstr First Natl Conf Hum Retrovir Relat Infect Natl Conf Hum Retrovir Relat Infect 1st 1993 Wash DC. 1993 Dec 12-16; 172.
Immune Deficiency Treatment Centre, Montreal General Hospital, Montreal, Canada.
Objective. To examine the impact of splenectomy on the course of human immunodeficiency virus (HIV)-related disease, and on the levels of T lymphocyte subpopulations. Methods: Cohort study of 47 HIV-infected individuals with a mean follow up period of 6 +/- 3.1 yrs. Seventeen HIV- infected patients were splenectomized at various times vis a vis HIV infection. Log rank statistic was used to compare survival of individuals splenectomized prior to, or soon after, HIV infection, those splenectomized during the asymptomatic phase, those splenectomized after AIDS was diagnosed and unsplenectomized subjects. Changes in CD4+, CD8+ and CD8+DR+ T cells subpopulations during the follow up period were measured and compared using linear regression models. Results: Patients splenectomized prior to infection with HIV tended to remain asymptomatic longer, had longer survival and lost CD4+ T cells at a slower rate compared with those splenectomized after HIV infection or unsplenectomized patients. Those splenectomized during the asymptomatic phase tended to survive approximately 1 year longer and remain AIDS free 9 months longer than unsplenectomized HIV-infected patients. Splenectomy of AIDS patients was not associated with improved clinical outcome. The relative risk of the non-splenectomized compared to splenectomized patients for developing AIDS as estimated by the odds ratio is 6.5 (p=0.01). Most of the patients responded to splenectomy by increased levels of CD4+ and CD8+ T cells. Conclusion: Absence of a spleen during the early stages of HIV infection appears to slow disease progress.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Antigens, CD4
- Antigens, CD8
- Cohort Studies
- HIV
- HIV Antibodies
- HIV Infections
- HIV Seropositivity
- Humans
- Lymphocyte Subsets
- Splenectomy
- T-Lymphocytes
- immunology
- surgery
Other ID:
UI: 102214606
From Meeting Abstracts