Karmochkine M, Oksenhendler E, Martinez F, Beaufils H, Valantin MA, Coutellier A, Idatte JM, Herson S; International Conference on AIDS.

Int Conf AIDS. 1996 Jul 7-12; 11: 100 (abstract no. Mo.B.1263).

Internal Medicine Dept. (Pr Herson), Hopital La Salpetriere, Paris, France. Fax: 33 1 42 16 10 58.

Objective: To determine efficacy and tolerance of steroid therapy in different types of renal disease encountered during HIV infection: specific HIV associated nephropathy (HIV-AN), immune-complex glomerulonephritis (ICGN) and interstitial nephritis (IN). Methods: Retrospective analysis of all cases of biopsy-proven renal disease treated with prednisone (0.5 to 1.5 mg/kg/d) in HIV patients followed in two french hospitals. Results: Six patients treated with prednisone during 11 plus or minus 7 months were included. Three patients were treated with zidovudine when renal disease occurred. Improvement in at least one renal parameter was observed in 5 cases and stabilization in one (Table). Two patients (n=1 & 2) relapsed when prednisone was tapered, and retreatment with higher dose was efficient. Early steroid-related complications were observed in all patients (mycobacterium avium complex, 1; esophageal candidiasis, 1; Kaposi's sarcoma, 2; hip osteonecrosis, 1; psychosis, 1). (table: see text) Conclusions: Although steroid therapy appears to be effective in the course of different types of renal disease associated with HIV infection, frequent side-effects limit the observed benefit. Overall risk-benefit issues remain to be clarified.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Disease Progression
• Glomerulonephritis
• HIV Infections
• HIV Seropositivity
• Humans
• Kidney
• Kidney Diseases
• Mycobacterium avium-intracellulare Infection
• Nephritis, Interstitial
• Prednisone
• Sarcoma, Kaposi
• adverse effects

Other ID:

• 96921327

UI: 102217226

From Meeting Abstracts