Hillemanns P, Ellerbrock TV, Dole P, Sun XW, Chiasson MA, Wright TC; International Conference on AIDS.

Int Conf AIDS. 1996 Jul 7-12; 11: 301 (abstract no. We.B.541).

Dept of Pathology, New York, NY, USA. Fax: (212) 305-5562.

Objective: To determine the prevalence of anal human papillomavirus (HPV) infections and anal cytologic abnormalities among HIV-seropositive and HIV-seronegative women. Methods One hundred two HIV-seropositive and 96 HIV-seronegative women were selected from a cohort of women with known HIV serostatus from the greater New York City metropolitan area. Women underwent a standardized interview and a gynecologic examination including a cytologic evaluation of the cervix and anus. Anal swabs were tested for HPV DNA using the Hybrid Capture assay. Results: Anal cytologic abnormalities were detected in 27 (28%) of the 102 HIV-seropositive women and in 6 (7%) of 96 HIV-seronegative women. Five (5%) of the anal smears from the HIV-seropositive women and 1 (1%) from the HIV-seronegative women had low-grade anal intraepithelial neoplasia (AIN). The remainder of the anal cytologic abnormalities were classified as mild squamous cytologic atypia. HPV DNA was detected in anal swabs from 30 (32%) of 102 HIV-seropositive and 2 (2%) of 96 HIV-seronegative women. Of the 33 patients with anal cytologic abnormalities, 19 (58%) had anal HPV DNA detected (P is less than 0.001). By multivariate logistic regression analysis, HIV-seropositivity was found to be an independent risk factor for both anal HPV infection and anal cytologic abnormalities and the strength of the association was greater in women with lower CD4 T-lymphocyte counts. Conclusion: The prevalence of both anal cytologic abnormalities and anal HPV infection are significantly increased among HIV-seropositive women. However, all of the anal cytologic abnormalities detected in this study were cytologically low-grade, and none had the cytologic features of a high-grade AIN. Therefore, our data do not support the routine use of anal cytology for screening HIV-seropositive women for anal disease.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Anal Canal
• Anus Diseases
• Anus Neoplasms
• Cervix Uteri
• Female
• HIV Infections
• HIV Seropositivity
• Humans
• New York City
• Papillomaviridae
• Prevalence
• Risk Factors
• Vaginal Smears

Other ID:

• 96923229

UI: 102219128

From Meeting Abstracts