Di Franco MG, Woods M, Spiegelman D, Knox T, Gorbach S; International Conference on AIDS.
Int Conf AIDS. 1996 Jul 7-12; 11: 102 (abstract no. We.B.3265).
Tufts University School of Medicine, Boston, MA, USA. Fax: (617) 636-5810. E-mail: mdifranc@opal.tufts.edu.
Objective: To determine the correlation between nutritional parameters in HIV-infected individuals and their CD4 counts. To compare estimated caloric needs and energy intake in the same population. Methods: We performed a cross-sectional analysis of 73 HIV-infected subjects, 57 males and 16 females enrolled in a longitudinal study on nutrition and HIV in Boston. Data has been gathered on measurements of nutritional status: body composition (Lean Body Mass (LBM) by Bioelectrical impedance (BIA), and body fat by anthropometrics), dietary intake (assessed by 3 day diet records [3ddr]) of calories, protein, and antioxidants, serum albumin and transferrin levels, and resting energy expenditure (REE) by indirect calorimetry. The outcome, CD4 counts, was used to assess progression of HIV infection. Spearman correlations were calculated. Results: Total energy intake was inversely related to CD4 counts (r= -0.23, p=0.052). Protein intake was not correlated with serum albumin and transferrin. There was a positive association between protein intake and LBM (r=0.41, p=0.0003) independent of percentage body fat estimated through anthropometric measurements. A significant inverse (r= -0.23, p=0.049) association was found between protein intake and percentage body fat. Correlations were calculated from estimated caloric needs by two methods (the Harris-Benedict equation and REE) and compared to total energy intake (3ddr). Both were highly statistically significant (p is less than 0.005) but with a low correlation coefficient (r=0.38, 0.35, respectively). Conclusions: Total protein intake was associated with LBM (a measure of wasting) at p=0.0003. CD4 count was inversely associated with total energy intake at p=0.052, but not statistically associated with protein intake. This suggests that dietary intake of protein impacts on the degree of wasting and that the AIDS wasting syndrome is more severe in individuals who are consuming an inadequate amount of protein.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Body Composition
- Boston
- CD4 Lymphocyte Count
- Calorimetry, Indirect
- Cross-Sectional Studies
- Diet Records
- Electric Impedance
- Energy Intake
- Energy Metabolism
- Female
- HIV Infections
- HIV Seropositivity
- HIV Wasting Syndrome
- Humans
- Longitudinal Studies
- Male
- Nutritional Status
Other ID:
UI: 102219515
From Meeting Abstracts