Torian LV, Murrill CS, Makki HA, Castellan-Paraison R, Benson DA, Weinstock HS, Weisfuse IB; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 4th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 4th 1997 Wash DC. 1997 Jan 22-26; 4th: 97 (abstract no. 177).
New York City Department of Health, New York, NY.
Objective: To estimate HIV seroincidence in repeat visitors (N=2055) to a high-seroprevalence sexually transmitted disease clinic in NYC. Main outcome measure: Serologic evidence of antibody to HIV in an initially seronegative individual. Design: Blinded longitudinal survey using remnant serum originally obtained for routine syphilis screening. Serum was salvaged from each visit, matched by patient identifiers, sequenced into chronological series, and banked. At the end of the study, all patient identifiers were removed and the serum tested for antibody to HIV-1 by enzyme immunoassay with confirmatory Western Blot. The Miragen(r) individual specific autoantibody profile assay was used to verify that all specimens in each seroconverter serum series were obtained from the same individual. Results: Among the initially seronegative patients (N=1854) there were sixteen seroconverters, for an Incidence Density (ID) of 1.24/100 person years (py). 13 of the seroconverters were male. Six of the 13 male seroconverters were men who have sex with men (MSM), and 5 of these MSM were nonwhite bisexuals. ID in all MSM was 3.3/100 py. ID in bisexual men was 5.2/100 py. ID in non-MSM males was 0.9/100 py. ID in females was 0.8/100 py. Incidence in men was associated with nonwhite race/ethnicity, same gender sex contact, and a history of gonorrhea. Conclusions: ID in females and non-MSM males fell within the predicted range of 0.5-1.0/100 py. ID in MSM was over three times that in non-MSM males and occurred primarily in nonwhite bisexuals, whose needs and concerns may not be addressed by prevention programs aimed at self-identified MSM.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Bisexuality
- Case-Control Studies
- Female
- Gonorrhea
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Incidence
- Longitudinal Studies
- Male
- New York City
- Seroepidemiologic Studies
Other ID:
UI: 102223341
From Meeting Abstracts