Poles MA, Meller JA, Lin A, Weiss WR, Gocke M, Dieterich DT; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 4th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 4th 1997 Wash DC. 1997 Jan 22-26; 4th: 193 (abstract no. 695).
NYU Medical Center, New York, NY.
Wasting decreases immune function, and is associated with decreased quality of life and increased mortality in patients with AIDS. Many modalities have been used in the treatment of this problem, but few promote positive nitrogen balance and increase body cell mass. We studied 21 patients with AIDS-related weight loss, defined as loss of greater than 5% usual body weight, or a baseline of less than 100% ideal body weight (IBW). Patients were treated with oxandrolone, 10 mg orally, twice daily. All subjects were men who acquired HIV through unprotected homosexual sex, with the exception of one woman who acquired the disease through unprotected heterosexual contact. The mean age of patients was 38 years, and mean CD4 count was 55. All patients were evaluated with bioelectrical impedance analysis (BIA). BIA mean values for weight, body cell mass (BCM), fat, intracellular water (ICW) and extracellular water (ECW) were calculated for patients at baseline, and then for those patients who took the medication for 30 days, 60 days, 90 days, and 120 days, respectively. Mean changes from baseline in weight, BCM, fat and ICW were significant (p is less than 0.05) at all points in time (except at 120 days, due to the small sample size at this time). At 30 days, weight increased by a mean of 6.5 pounds, BCM increased by a mean of 3.4 pounds, fat increased by a mean of 1.6 pounds, and ICW increased by a mean of 1.4 liters. At 60 days, weight increased by a mean of 12.9 pounds, BCM increased by a mean of 6.9 pounds, fat increased by a mean of 3.0 pounds, and ICW increased by a mean of 2.9 liters. At 90 days, weight increased by a mean of 11.3 pounds, BCM increased by a mean of 4.2 pounds, fat increased by a mean of 5.2 pounds, and ICW increased by a mean of 1.8 liters. At 120 days, weight increased by a mean of 16.0 pounds, BCM increased by a mean of 6.6 pounds, fat increased by a mean of 6.8 pounds, and ICW increased by a mean of 2.7 liters. Change in ECW was significant (p is less than 0.05) only at 90 days. At that time, ECW was decreased by a mean of 1.1 liters from baseline. Of note, values for mean body composition, including % ideal body weight, % BCM, and % fat were also recorded at baseline, and at 30-day intervals thereafter, and were noted to rise steadily throughout the study period. Percent IBW increased from 92.2% at baseline to 101.3% at 90 days and to 106.7% at 120 days. Treatment with oxandrolone resulted in a significant (p is less than 0.05) increase in weight gain, and importantly, in BCM at 90 days. A significant (p is less than 0.05) increase in ICW and a significant (p is less than 0.05) decrease in ECW were also found to occur at 90 days. Final analysis for the 120-day follow-up has not been completed at this time. Thus, the common nutritional abnormalities that occur in AIDS-related weight loss and wasting were reversed.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- Body Composition
- Body Weight
- CD4 Lymphocyte Count
- Diet, Reducing
- Electric Impedance
- Female
- Gastroplasty
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- Nutritional Status
- Obesity
- Weight Gain
- drug therapy
- surgery
- therapy
Other ID:
UI: 102223525
From Meeting Abstracts