Ellerbrock T, Wright T, Fothergill A, Conley L, Chiasson MA, Rinaldi M; Conference on Retroviruses and Opportunistic Infections.

Program Abstr 4th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 4th 1997 Wash DC. 1997 Jan 22-26; 4th: 125 (abstract no. 329).

Centers for Disease Control and Prevention, Atlanta, GA.

Objective: To compare species and antifungal susceptibilities of oral and vaginal yeast isolates from HIV-infected (HIV+) and uninfected (HIV-) women. Methods: Oropharyngeal and vaginal yeast cultures were obtained from 175 women, 97 of whom were HIV+ and 78, HIV-. In vitro susceptibility testing was performed according to the tentative NCCLS standard (M27-T). Results: Sixty-seven percent (65/97) of HIV+ and 63% (49/78) of HIV- women had positive oral cultures (OR = 1.2; NS), while 29% (28/97) of HIV+ and 19% (15/78) of HIV- women had positive vaginal cultures (OR = 1.7; NS). The species and fluconazole patterns in yeast cultures of these HIV- and HIV+ women were: (Table: see text) Four isolates were resistant to miconazole; none to clotrimazole or amphotericin. Conclusion: In vitro resistant to fluconazole is not uncommon in vaginal yeast isolates from HIV+ and HIV- women. This resistance could become a serious problem for HIV+ women as more patients are treated with fluconazole.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Amphotericin B
• Antifungal Agents
• Candida
• Candida albicans
• Candida glabrata
• Female
• Fluconazole
• HIV Infections
• HIV Seropositivity
• Humans
• In Vitro
• Oropharynx
• Saccharomyces cerevisiae
• Yeasts

Other ID:

• 97926731

UI: 102225257

From Meeting Abstracts