Ng CS, Fuller A; Australasian Society for HIV Medicine. Conference.
Annu Conf Australas Soc HIV Med. 1997 Nov 13-16; 9: 133 (poster no. P34).
Alfred Hospital, Melbourne.
OBJECTIVE: To report cases of Selenium deficiency and associated cardiomyopathy in HIV infected patients. DESIGN: Retrospective review of patients clinical history, findings, cardiological investigations and laboratory results. SETTING: Alfred Hospital, Melbourne from June 1996 to July 1997. RESULTS: There were 4 patients during the study period who were found to be Selenium deficient. 3 of these had clinical, radiographic and echocardiographic evidence of cardiomyopathy with one death attributed to the condition. 2 patients given Selenium replacement had reversal of their cardiac dysfunction with both clinical and echocardiographic improvement. CONCLUSION: Selenium deficiency is reported in HIV infected patients in both early and end stage disease. This deficiency is associated with dilated cardiomyopathy especially in the setting of severely cachectic AIDS patients. Our experience shows Selenium replacement can reverse the cardiomyopathy in milder cases. It is therefore important to measure Selenium levels in all malnourished or late stage HIV patients to detect and prevent this potentially fatal complication.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Cardiomyopathies
- Cardiomyopathy, Dilated
- HIV Infections
- HIV Seropositivity
- Humans
- Malnutrition
- Selenium
- Vitamin A Deficiency
- metabolism
- organization & administration
Other ID:
UI: 102226365
From Meeting Abstracts