Sogolow E, Semaan S, Johnson WD, Neumann M, Ramirez G, Sweat M, Doll LS; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 239 (abstract no. 14283).

CDC, Atlanta, GA 30333, USA.

BACKGROUND: This study examines the effects of HIV prevention interventions on safer sex behaviors, using the US Centers for Disease Control and Prevention's new Prevention Research Synthesis (PRS) database. METHODS: The PRS includes HIV intervention studies that are published and unpublished, US-based and international, from 1988 to present, and that meet relevance (e.g., behavioral or HIV/STD outcomes) and methodological criteria (e.g., unbiased assignment to intervention and control/comparison groups). Information on populations, age groups, setting, and other factors is coded for each study. Meta-analytic techniques are used to combine individual study safer sex outcomes results. In each meta-analysis we calculated an overall weighted average effect size (WA) and 95% confidence intervals (CI) for a set of studies and then for sub-groups of that set. RESULTS: To data, PRS includes 82 studies which meet all criteria, of which 72 are US-based. Of the 72, 22 reported sufficient safer sex data for meta-analysis. For the 22 studies, meta-analysis results for the effects of interventions on sexual risk behaviors were positive (indicating intervention effectiveness) (WA = .28) and significant (CI = 0.21 to 0.34) (CI not including zero). Similarly, meta-analysis results were positive and significant with target populations, age groups, and settings: with men who have sex with men [n = 5 studies, WA = .23, CI = (0.11 to 0.34)], heterosexuals [n = 10, WA = .37, CI = (0.26 to 0.47)], and substance users [n = 7, WA = .21 CI = (0.09 to 0.33)]; with youth [n = 5, WA = .34, CI = (0.20 to 0.48)] and adults [n = 17, WA = .26, CI = (0.18 to 0.33)]; and with clinic/institution [n = 11, WA = .37, CI = (0.26 to 0.48)] and non-clinic/institution [n = 11, WA = .23, CI = (0.15 to 0.31)]. CONCLUSIONS: Meta-analyses show HIV prevention interventions are effective for reducing sexual risk behavior overall and in different populations, age groups, and settings. The overall WA of .28 is equivalent to a 14% risk difference favoring those who received the intervention. Improved collection and reporting of data are needed to increase the number of studies available for analysis.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Adult
• Centers for Disease Control and Prevention (U.S.)
• HIV Infections
• HIV Seropositivity
• Humans
• Male
• Meta-Analysis
• Population
• Risk-Taking
• Safe Sex
• Sexual Behavior
• Substance-Related Disorders
• methods

Other ID:

• 98392023

UI: 102228150

From Meeting Abstracts