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Cystoid macular edema in diabetic patients after treatment for CMV retinitis (CMVR) with ganciclovir implants.

Lieberman R, Orellana J, Roseman JB; International Conference on AIDS.

Int Conf AIDS. 1998; 12: 567 (abstract no. 32236).

Mount Sinai School of Medicine, New York, NY, USA.

OBJECTIVE: To determine if non-insulin dependent diabetes mellitus (NIDDM) or insulin dependent diabetes mellitus (IDDM) impacts upon the development of cystoid macular edema (CME) after ganciclovir implant (Vitrasert) surgery. DESIGN: Retrospective study. METHODS: The records of 54 patients (76 eyes) who had previously received ganciclovir implants were analyzed (98 procedures performed). Patients were divided into three groups: those having insulin dependent diabetes mellitus (IDDM), those having non-insulin dependent diabetes mellitus (NIDDM), and those not having diabetes (groups 1, 2, and 3). All patients received identical postoperative medications and had the implants placed using the same, standard surgical technique. All patients had frequent, full ophthalmic examinations, including indirect ophthalmoscopy and contact lens examination of the macula. Fluorescein angiography was performed to determine the status of the macula, if deemed necessary on examination. RESULTS: Of 54 patients who received ganciclovir implants between 12/94 and 12/97 (76 eyes), 14 patients (22 eyes) were found to be diabetic. Six (10 eyes) had IDDM, and 8 (12 eyes) had NIDDM. Four patients (66%) or 28% of procedures in group 1 developed CME, while 4 (50%) or 30.8% of procedures in group 2 developed CME. Of the 40 non-diabetic patients, 4 (10%) developed CME, or 5.6% of procedures. There is a statistically significant difference between the groups. CONCLUSION: IDDM may increase the patient's chance of developing CME after implant surgery. Careful postoperative assessment of the macula is warranted, especially in diabetic patients.

Publication Types:
  • Meeting Abstracts
Keywords:
  • Aftercare
  • Cytomegalovirus Retinitis
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2
  • Fluorescein Angiography
  • Ganciclovir
  • Humans
  • Macula Lutea
  • Macular Edema
  • Retrospective Studies
Other ID:
  • 98396208
UI: 102229751

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