Rangsin R, Chiu J, Sirisopana N, Eiumtrakul S, Khamboonruang C, Beyrer C, Brown A, Nelson K, Markowitz L; International Conference on AIDS.
Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. MoPpC1032.
R. Rangsin, Pra Mong Kut Klao College of Medicine, Thailand, 4 East 32nd St., Apt.211, Baltimore MD 21218, United States, Tel.: +1 410 467 56 39, Fax: +1 410 955 18 36, E-mail: rrangsin@jhsph.edu
Background: Studies of HIV-1 incidence among young Thai men could give a reliable estimate of the recent epidemic in Thailand. This study evaluated HIV-1 incidence, 4-6 years after discharge from Royal Thai Army (RTA) among 21 years old men who were discharged from RTA in 1993-1994 after 2 years of service. Methods: A retrospective cohort study was conducted of 255 men who were HIV-1 seronegative at the time of discharge from RTA in 1993-1994. The study population was randomly chosen from men in 12 provinces (7 upper North, 1 lower North, 3 Northeast and Bangkok). A community survey to follow this cohort was conducted with Physical examination, behavioral interviews and phlebotomy, from Nov.1998 - Sep.1999. HIV-1 serostatus was determined by ELISA and confirmed by Western Blot. T. pallidum infection was determined by RPR and confirmed by TPHA. CD4 count was determined and HIV-1 RNA was quantitated. Incidence was determined using person-time analysis. Results: 232(90.9%) of 255 subjects have been identified. 8(3.4%) were deceased and 185(72.5%) were enrolled into the survey. The median age at discharge and follow-up were 23 and 28 years, respectively. The median follow-up time was 5.1 years. The subjects provided a total of 970 person-years of follow-up; 3 of 185 were HIV positive; HIV-1 incidence = 0.31 (95%CI = 0.28-0.34) per 100 person-years. All of the HIV-positive men were asymptomatic; Range of CD4 counts was 309-522/?l. HIV-1 RNA was detected in each of 3 the HIV-1 seropositives(range;10742 - 70254 copies/mL). Also 4(2.2%) men were serologically positive for active syphilis infection; all these men were HIV negative Conclusion: Our study found a low incidence of HIV-1 infection among young Thai men during the past 6 years. The HIV-1 incidence rate was 0.31 per 100 person-years. Nevertheless, continued efforts are needed to further decrease the risk of HIV in this population and prevent transmission of HIV positive men to their sexual partners.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- CD4 Lymphocyte Count
- Cohort Studies
- Government Agencies
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Incidence
- Male
- Patient Discharge
- Retrospective Studies
- Thailand
Other ID:
UI: 102237956
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