Wolf E, Jaegel-Guedes E, Mueller S, Pascucci R, Moser-Juenemann C, Jaeger H; International Conference on AIDS.
Int Conf AIDS. 2000 Jul 9-14; 13: abstract no. WePpB1382.
E. Wolf, Kis - Curatorium for Immunedeficency, Mozartstrasse 3, 80336 Muenchen, Germany, Tel.: +49 89 558 703 15, Fax: +49 89 599 893 53, E-mail: mucres@aol.com
Rationale: Peripheral fat wasting, trunkal obesity, breast enlargement, gynecomastia are among the clinical variables seen in the so-called lipodystrophy syndrome (LD) in HIV+ patients (pts). The pathogenesis of LD remains unclear. Possible risk factors for the development of LD have neither been identified nor quantified Besides associated metabolic changes, the role of hormones has yet to be investigated. Objectives: To assess estradiol and testosterone levels in HIV+ men with and without LD. Methods: Single point measurements (between 9-11 a.m) of estradiol and of total and free testosterone levels were performed in 96 pts. The presence of LD was based on LD-associated clinical findings Following parameters were included in the analysis: time since 1st+HIV-test, duration of ART, current ART, VL, (D4 cell count, prior AIDS events, blood lipids and serum glucose. Results: To date N = 77 pt charts have been analysed. 51/77 (66%) HIV+ were diagnosed as lipodystrophic. 26 (34%) had no clinical diagnosis of LD. Splitting the pts into "LD" and "no LD" categories, no differences could be observed in time since 1st HIV+ test (mean 6.4 yrs) nor in duration of ART (4.4 yrs) Further results are listed in the following Table (statististic. tests: frequencies: chi-square, cont. variable.: Mann-Whitney) Med. Med. AIDS pts BMI High estradiol Low free testosterone CD4/m l VL[cop/ml] (>35 pg/ml) (>8 5 pg/ml) LD 328 22,379 47% 23.0 14/50 (28%) 11/51 (22%) NO LD 381 39,990 30% 24.2 5/27 (19%) 7/26 (27%) p-value ns ns OR: 2; ns 0.06 OR: 1.7; ns OR: 0 75 ns Conclusion/Discussion: Although estradiol levels above the upper normal limit were observed more frequently in men with LD, they did not reach significance in univariate analysis. Lipodystrophic men tend to have a lower BMI than controls and a more advanced disease pattern. Further analysis is needed to elucidate whether the lacking association between hormone levels and LD is due to low sample size, and will include other possible relevant factors in a logistic regression model.
Publication Types:
Keywords:
- AIDS Vaccines
- Acquired Immunodeficiency Syndrome
- Biological Assay
- Estradiol
- Gynecomastia
- HIV Infections
- HIV Seropositivity
- HIV-Associated Lipodystrophy Syndrome
- Hematologic Tests
- Humans
- Lipodystrophy
- Male
- Risk Factors
- Single Person
- Testosterone
Other ID:
UI: 102240326
From Meeting Abstracts