Silbermann B, Salmon D, Questel F, Heripret L, Pecqueux L, Diamant-Berger O, Sicard D; Conference on Retroviruses and Opportunistic Infections.
Program Abstr 8th Conf Retrovir Oppor Infect Conf Retrovir Oppor Infect 8th 2001 Chic Ill. 2001 Feb 4-8; 8: 109 (abstract no. 227).
Cochin Hosp.
Background: In recent years the care and treatment of patients (pts) suffering from accidental sexual exposure to HIV have shown a trend to harmonisation. The objective of this study was to describe the different characteristics of the pts seen for rape at Cochin Hospital, their primary therapeutic care, and their clinical and biological follow-up. Methods: A retrospective study of pts referred by Hotel-Dieu medical-judicial ER after an accidental sexual exposure by rape during the year 1999 was performed. Results: Of the 111 pts in which a treatment was begun and who were referred at Cochin Hospital, 66 were seen at least one time (59.5%). The average age was 25 years old. Sex ratio M/F was 0.09. Types of aggressions were: 49 receptive vagina l(81.6%), 14 receptive anal (23.3%), 21 receptive oral (35%) and 20 combined cases (33.3%). Increased risk factors for HIV transmission were present in 81.6% of cases (49/60), with 55% ejaculation and 33.3% bleeding- trauma. Time scale between sexual aggression and beginning of the chemoprophylaxis was 10.30 hours. Of the 66 pts, 28 started Combivir (42.4%) and 38 started Combivir/Crixivan (57.6%). After the first consultation, treatment was stopped in 2 pts (no sexual penetration), treatment was reinforced in 9 pts (6 Crixivan, 2 Viramune, 1 Sustiva). Among the 64 remaining pts still undergoing treatment, only 27 pts (42.2%) continued their follow-up: 18 (28.1%) continued their treatment until M1, while 9 stopped (3 side effects, 3 negative HIV serological status of the attacker, 3 by the pts' choice). Of the 29 pts who received and strictly followed their treatment, 12 (41.4%) presented side effects to treatment (7 digestive intolerance, 1 nephrolithiasis while on Crixivan, 3 benign rashes, 1 toxidermy and pancytopenia while on Viramune). There was no seroconversion for HIV, HBV, and HCV. However, only 27 pts (40.9%) underwent another HIV serology test at M1, 10 (15.1%) at M3, and 2 (3.3%) at M6. Conclusions: Victims presenting at Cochin Hospital have a high risk of HIV contamination, the reasons being multiple intercourse, ejaculation, and bleeding-trauma. However, only 26% (29/111) of the pts accepted and underwent a prophylactic treatment. This can be explained by the psychological trauma suffered by the pts. The results of the year 2000 will be also presented.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Chemoprevention
- Female
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- Rape
- Retrospective Studies
- Risk Factors
Other ID:
UI: 102244008
From Meeting Abstracts