MALTEZOU HC, KAFETIZIS DA, ROLSTON KV; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 599 (abstract no. 735).

Univ. of Athens, P & A Kyriakou Children's Hosp., Athens, GREECE

The development of pre-engraftment bacterial infections in 130 HSCT recipients who received antibacterial prophylaxis (group A) was compared with those of 59 pts who did not (group B). Prophylaxis included vancomycin (62 pts), vancomycin/norfloxacin (56), penicillin/norfloxacin (8), doxycycline/norfloxacin (2), and minocycline/norfloxacin (2). The duration of neutropenia was similar in the two groups. 107 (82%) pts of group A and 59 (100%) of group B developed febrile episodes (p=0.001). The median time to first febrile episode was 12 days (10-16) for group A and 9 days (7-10) for group B (p0.001). Documented infections developed in 36 (28%) pts of group A and 26 (44%) of group B (p=0.26). Overall, bacterial infections occurred in 36 (28%) pts of group A and 30 (51%) of group B (p=0.002). Gram-positive, gram-negative and polybacterial/anaerobic infections accounted for 10 (28%), 15 (42%) and 11 (30%) of bacterial infections in group A, and 13 (43%), 8 (27%) and 9 (30%) in group B (p=.033). Empiric antibacterial treatment (rx) was administered to 112 (86%) pts of group A and 59 (100%) of group B (p=0.003). The incidences of fever of unknown origin, fungal infections, use of empiric antifungal rx, and mortality were similar in the two groups. Significant risk factor for bacterial infections was a non-prophylaxis policy (Odds Ratio: 2.79; 95% Confidence Interval: 1.20-6.47; p=0.017). In conclusion, antibacterial prophylaxis significantly reduced the incidence of febrile episodes, documented infections, and bacterial infections, and the use of empiric antibacterial rx in HSCT recipients.

Publication Types:

• Meeting Abstracts

Keywords:

• Anti-Bacterial Agents
• Antibiotic Prophylaxis
• Antifungal Agents
• Bacterial Infections
• Bone Marrow Transplantation
• Fever
• Hematopoietic Stem Cell Transplantation
• Humans
• Incidence
• Mycoses
• Neutropenia
• Norfloxacin
• Physical Therapy Modalities
• Transplantation Conditioning
• Transplantation, Autologous
• Transplantation, Homologous
• drug therapy
• microbiology
• prevention & control
• surgery
• therapy
• transplantation

Other ID:

• GWAIDS0008606

UI: 102246103

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