ARVIEUX C, GUGGENBUHL P, POLLARD JL, LEROY M, CHA-MINJOLLE S, GOUGEON A, GOLDSCHILD M, GARRIN E, MOISAN A; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 628 (abstract no. 1676).
GERIO, Groupe d'Etudes et de Recherches sur l'Infection Osteo-articulaire, Rennes, FRANCE.
BACKGROUND: A multidisciplinary group has been created in Nov. 1991 in order to follow up all patients with bone or joint infections seen at the university hospital of Rennes, France.METHODS: Retrospective study of patients with joint prosthesis infection registred between Nov 1[st], 1991 and Dec. 31[st], 1996, in order to stand back more than two years after the diagnostic procedure at Dec. 31[st], 1998. Patients were considered as cured if there was no clinical evidence of infection on Dec; 31[st] 1998. The function of the joint was evaluated at the same date (no sequels, minor or major sequels). For patients who died during the study period, death was classified as related or unrelated to infection.RESULTS: 33 patients were included. Median age was 67 (39-92). Almost all joints were hips or knees. Regarding the onset of infection, patients had been reported to the group before one month for 41%, between one month and one year for 34% or after one year for 25%. Staphylococcus was the most frequent pathogen (78%), Meticillin sensitive (34%), Meticillin Resistant (22%) S. aureus, and coagulase negative Staphylococci (22%). Patients were treated with different regimen of surgical procedures and mainly IV bitherapy for 21 days followed by oral combinations for a mean of 6 months. Mean follow up after the end of antibiotics was 483 days (0-1200, including patients with final antibiotic therapy on Dec. 31[st] 1998). Cure was obtained in 76% of patients. Squels were minor in 33%, major in 39%. All patients for whom arthrodesis had been performed were classified as having major functional sequels, even if walking was possible without pain. There were four deaths, 3 (9% of patients) related to infection.CONCLUSIONS: Despite a high rate of bacteriological cure, sequels of infection are important and death related to infection is close to 10%. Sooner multidisciplinary follow-up of such patients could improve joint function. The multidisciplinary procedure is actually applied in our institution as soon as infection appears.
Publication Types:
Keywords:
- Animals
- Anti-Bacterial Agents
- Arthritis, Infectious
- Arthroplasty, Replacement
- Arthroplasty, Replacement, Hip
- Arthroplasty, Replacement, Knee
- Communicable Diseases
- France
- Humans
- Infection
- Joint Prosthesis
- Prosthesis Implantation
- Prosthesis-Related Infections
- Research Design
- Retrospective Studies
- surgery
Other ID:
UI: 102246181
From Meeting Abstracts