MALKIN JE; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 688 (abstract no. 1745).
Inst. Alfred Fournier, Paris, FRANCE.
BACKGROUND: Genital herpes simplex virus (HSV) infection is considered an important public health problem, affecting millions of people worldwide. New antiherpes virus agents have been developed with the view to gain better oral bioavailability and/or intracellular pharmacokinetics. Twice-daily therapy with famciclovir was shown to be effective for episodic therapy for recurrent genital herpes in a large placebo-controlled trial. However, no study has been published to date comparing famciclovir and acyclovir.METHODS: A multicenter, double-blind, double-placebo, randomized, parallel-design, equivalent-assessed study was conducted to compare famciclovir and acyclovir in recurrent genital HSV infection. Two hundred and four patients were included. Patients self-initiated oral therapy with 125 mg of famciclovir twice daily or acyclovir 200 mg 5 times daily for 5 days. The principal end-point of the study was the complete healing of lesions. Duration of the complete resolution of all symptoms and safety were also considered.RESULTS: The groups were well matched for baseline characteristics, except for age (median value 45 vs 40 y, p = 0.01). The population was 69% female and 31% male. The mean lesion healing time was 5.13 days (CI95% [4.74 ; 5.52]) in the famciclovir group vs 5.38 days (CI95% [4.96 ; 5.80]) in the acyclovir group; the crude difference (Delta ) between groups was 0.25 (CI95% [-0.32 ; 0.82]). All symptoms resolved in 5 days (range 0-9) vs 5 days (range 1-10). No significant adverse reactions were noted.CONCLUSIONS: Twice-daily famciclovir was as effective and safe in the treatment of recurrent genital HSV infection as 5-times-daily acyclovir.
Publication Types:
Keywords:
- 2-Aminopurine
- Acyclovir
- Case-Control Studies
- Clinical Trials as Topic
- Double-Blind Method
- Female
- Herpes Genitalis
- Humans
- Male
- Placebos
- Recurrence
- Simplexvirus
- Treatment Outcome
- famciclovir
Other ID:
UI: 102246326
From Meeting Abstracts