MCGINNIS M, NORDOFF NG, RYDER NS; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 1999 Sep 26-29; 39: 572 (abstract no. 1520).

Dept. Pathology, Univ. TX Med. Branch, Galveston, TX

Recent clinical studies have indicated that terbinafine has therapeutic application beyond infections involving hair, nail and skin. In vitro susceptibility testing data and published case reports show that its activity is similar to itraconazole. Terbinafine is active against a broad spectrum of pathogenic fungi, but its activity in Penicillium marneffei has not been previously reported. In order to assess potential utility of terbinafine in this important emerging pathogen, we evaluated terbinafine against 26 isolates of P. marneffei in comparison with itraconazole. A modification of the NCCLS macrobroth dilution yeast testing protocol was employed. MIC assays were incubated at 35C. The MIC was the first drug dilution having no growth at 48hrs after the growth control tubes could be read. The MFC was determined by plating 10micro-l from each MIC drug dilution having no growth onto Sabouraud glucose agar incubated at 30C. The MFC was the dilution at which growth was absent at 24hrs of incubation. The QC strains Candida albicans (ATCC 90028), C. krusei (ATCC 6258) and C. parapsilosis (ATCC 22019) were used in all assays. The MIC values in microg/ml were: terbinafine 0.03-1.0 (mean 0.29), itraconazole 0.03-0.5 (mean 0.08). The MFC values in microg/ml were: terbinafine 0.03-32 (mean 17.31), itraconazole 0.03-32 (mean 14.79). Primary fungicidial activity (MFC within 2 dilutions of MIC) was noted with terbinafine in 8 isolates and with itraconazole in 4 isolates. In conclusion, the data indicates that terbinafine is active in vitro against P. marneffei and may have a previously unrealized role in the management of infections caused by this fungus.

Publication Types:

• Meeting Abstracts

Keywords:

• Candida albicans
• Evaluation Studies
• Fungi
• In Vitro
• Itraconazole
• Microbial Sensitivity Tests
• Naphthalenes
• Penicillium
• terbinafine

Other ID:

• GWAIDS0009336

UI: 102246834

From Meeting Abstracts