SPRUANCE SL, TYRING S, BLEAZARD C, VANDERSTRATEN M, SMITH M, MENG T; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 263.

Univ. of Utah, Salt Lake City, UT

BACKGROUND: R-848 is a topically-active immune response modifier that selectively induces cytokines, including IFN-alpha and IL-12. R-848 decreased recurrences in a guinea pig model of genital herpes.METHODS: To determine if topical application of R-848 to genital herpes lesions decreases recurrences, immune competent adults with a history of >/= 6 recurrences/yr were sequentially randomized to a 3 week treatment of R-848 gel or vehicle (2:1) in dosing cohorts of 12. Study drug was applied to lesion(s) Publication Types:

• Meeting Abstracts

Keywords:

• Administration, Topical
• Adult
• Clinical Trials as Topic
• Cytokines
• Double-Blind Method
• Female
• Herpes Genitalis
• Humans
• Imidazoles
• Interferon-alpha
• Male
• R 848
• Recurrence

Other ID:

• GWAIDS0009446

UI: 102246944

From Meeting Abstracts