MORTON T, SHAW B, BASELSKI VS; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 110.
Univ. of Tennessee, Memphis, TN
During calendar years 1994-1999, Memphis Pathology Lab. performed susceptibility testing on 2,268 isolates of S. pneumoniae consisting of the oxacillin (OX) disk screening test followed by E-test confirmation of OX-resistant strains to Penicillin (PEN) and ceftriaxone (CTX) using NCCLS interpretive criteria. During that time period OX-resistance showed a steady increase from 38% in 1994 to approximately 50% in 1998-1999. Among OX-resistant isolates, 10% or less failed to demonstrate some degree of nonsusceptibility to PEN by E-test. Among the remainder, a trend toward increasing PEN MICs was noted with 75% I and 19% R in 1994, and 55% I and 36% R by 1999. In contrast, CTX showed a trend toward increasing susceptibility with 48% S, 27% I, and 18% R in 1994, but 61% S, 29% I, and 10% R in 1999. During that same period, although more isolates were tested 312 to 442, source (invasive vs. noninvasive) did not vary, and from 1996-1999, demographic features (age and sex distribution, inpatient vs. outpatient) also did not vary. Reasons for the apparent shift toward increasing CTX susceptibility are not clear, but could have implications for design of empiric or therapeutic antibiotic regimens.KEYWORDS: Ceftriaxone; Penicillin; Streptococcus pneumoniae
Publication Types:
Keywords:
- Anti-Bacterial Agents
- Ceftriaxone
- Microbial Sensitivity Tests
- Oxacillin
- Penicillins
- Streptococcus pneumoniae
Other ID:
UI: 102248653
From Meeting Abstracts