RAZ R, MINES M, KENESS Y, COLODNER R; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 141.

Haemek Med. Ctr., Afula, Israel

BACKGROUND: The pneumonia PORT cohort study defined score risk groups in order to estimate the prognosis of patients with community acquired pneumonia (CAP). Procalcitonin (PCT) serum level is considered a useful marker of bacterial infections and it rises early in contrast with C-reactive protein (CRP), which appears later and is not specific for bacterial infections. The aim of the present study was to evaluate correlation between serum levels of PCT and CRP in hospitalized patients with CAP and pneumonia PORT cohort study scoring. Materials andMETHODS: Serum PCT and CRP levels of 31 hospitalized patients with CAP were taken on admission. Patients were classified according to the risk group score (I - V). PCT was measured with an immunoluminometric assay (Brahms Diagnostica, Germany) and CRP with CRPLX (Roche Diagnostics, Germany).RESULTS: From the 31 patients evaluated, 18 showed high PCT serum levels (mean 10.3 ng/ml) and 13 showed normal values (mean 0.17 ng/ml). In all the patients with elevated PCT values, CRP presented high serum level (mean 285.9 mg/dl). CRP levels were also elevated in 12/13 patients with normal PCT values (mean 102 mg/dl). The mean risk score of both groups of patients, with high and normal PCT values, were similar (108.0 and 104.0 respectively). No correlation was found between high serum PCT levels and severity of disease; 7/18 patients (38.8%) in the high PCT level group and 4/13 (30.7%) in the normal PCT level group were scored with >130 points (group V). In addition, three patients belonging to score group V died: two of them showed high PCT levels and one showed normal level.CONCLUSIONS: This pilot study did not show any correlation between serum levels of PCT-CRP and severity of disease or outcome of hospitalized patients.KEYWORDS: Pneumonia; Procalcitonin; Prognosis

Publication Types:

• Meeting Abstracts

Keywords:

• Bacterial Infections
• Biological Markers
• C-Reactive Protein
• Calcitonin
• Cohort Studies
• Germany
• Humans
• Pneumonia
• Prognosis
• Protein Precursors
• Serum Amyloid A Protein
• procalcitonin

Other ID:

• GWAIDS0011188

UI: 102248686

From Meeting Abstracts