WANG JH; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 455.
Section of Infectious Diseases, Dept. of Internal Med., China Med. Coll.-Hosp., Taiwan Republic of China
Bacterial vaginosis is the most prevalent disease of the female genital tract. In spite of various effective antibiotics in the treatment of bacterial vaginosis, its high relapse rate is a common problem. Bacterial species causing bacterial vaginosis are complicated and fastidious to conventional culture methods. It is impractical and inadequate to use culture methods to guide antibiotics use. Gram stain of vaginal secretion is a practical tool to establish the diagnosis of bacterial vaginosis. However, it is not a good guide for choosing antibiotics and prediction of relapse. We enrolled 78 cases of Gram stain-proven bacterial vaginosis and tried to use Gram stain as a predictor of relapse after 1 week of treatment with metronidazole. Possible predictive factors for relapse in Gram stain were analyzed, including absence of large gram-positive rods, presence of small gram-negative rods, small gram-variable rods, curved gram-variable rods, or gram-positive cocci. Grams stain was repeated immediately after treatment, and at 1 and 3 months after treatment. All cases showed beneficial clinical effect after metronidazole treatment. Eighteen cases (23.1%) relapsed during the follow-up period. All 16 cases with significant gram-positive cocci in pretreatment smears relapsed after metronidazole treatment. Presence of small gram-negative rods, small gram-variable rods, and curved gram-variable rods, or absence of large gram-positive rods were not a predictor of relapse. Gram-positive cocci found in pretreatment smear was a good predictor of relapse after metronidazole treatment.KEYWORDS: Bacterial vaginosis
Publication Types:
Keywords:
- Female
- Gentian Violet
- Gram's stain
- Gram-Negative Bacteria
- Gram-Positive Cocci
- Metronidazole
- Phenazines
- Recurrence
- Staining and Labeling
- Vagina
- Vaginosis, Bacterial
Other ID:
UI: 102248945
From Meeting Abstracts