RAHMAN M, MONIRA S, SULTAN Z, NAHAR S, ALBERT MJ; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 454.

Intl. Ctr. for Diarrhoeal Disease Res., Bangladesh, Dhaka, Bangladesh

BACKGROUND: Ciprofloxacin is recommended for treatment of uncomplicated gonorrhea and is currently used for empirical treatment of gonorrhea in Bangladesh. However, in a recent study in female sex workers (FSWs) in Bangladesh, in vitro resistance of N. gonorrhoeae to ciprofloxacin was found frequently. The correlation between in vitro susceptibility of N. gonorrhoeae to ciprofloxacin and the treatment outcome was studied. Materials andMETHODS: FSWs who were culture positive for N. gonorrhoeae were treated with 500 mg single dose ciprofloxacin. A second endocervical swab was collected from culture positive cases after 7-10 days and those who remained culture positive were considered as treatment failure. Antimicrobial susceptibility and minimum inhibitory concentrations (MICs) of the primary isolates as well as second isolates from treatment failure cases were determined. Serotype and serovar distribution and genotype of the isolates were also determined.RESULTS: Eighty culture positive FSWs were enrolled in the study and among them 66 were available for follow-up. The second specimen was culture positive for gonorrhea in 25 cases (37.8%). Ninety-six percent (24/25) of the primary isolates in the treatment failure group were resistant and 4% (1/24) had reduced susceptibility to ciprofloxacin versus 5% (2/41) of the isolates in success group had reduced susceptibility to ciprofloxacin (P<0.001). Pre- and post-treatment isolates from treatment failures showed identical serotype, serovar and PCR-RFLP patterns. Eighty-four percent (21/25) of the isolates from the failure group and 54% (22/41) from the success group belonged to serotype B. Overall 37.8% of the gonococcal isolates were resistant to ciprofloxacin. Conclusion: A good correlation between in vitro resistance and treatment failure was observed.KEYWORDS: Ciprofloxacin; Neisseria gonorrhoeae; Treatment

Publication Types:

• Meeting Abstracts

Keywords:

• Bangladesh
• Ciprofloxacin
• Female
• Gonorrhea
• In Vitro
• Microbial Sensitivity Tests
• Neisseria gonorrhoeae
• Prevalence
• Treatment Failure
• Treatment Outcome

Other ID:

• GWAIDS0011457

UI: 102248955

From Meeting Abstracts