WAREHAM DW, DAS S, SOLANKI K, BRITTON K, AMARAL H, BHATNAGAR A, KATAMIHARDJA H, MALAMITSI J, MOUSTAFA H, SOROA V, SUNDRAM F, PADHY A; Interscience Conference on Antimicrobial Agents and Chemotherapy.

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 484.

St. Bartholomews Hosp., London, United Kingdom

BACKGROUND: The diagnosis of deep-seated infection is a challenging problem. A novel radiopharmaceutical, 99mTechnetium labelled ciprofloxacin (Infecton), is taken up in - vitro by a wide range of live but not dead bacteria and has been used successfully to image sites of bacterial infection. A kit format, with extended shelf life, was developed and shown in a smaller study to be comparable to the original preparation. We performed an international multi-centre trial to evaluate the kit format in a diverse range of infections.METHODS: 753 patients thought to be suffering from a variety of infections were administered 300 - 400 MBq of Infecton intravenously. Infections were classified according to the CDC definitions for nosocomial infection. Whole body images were taken 1, 4 and sometimes 24 hrs later.RESULTS: No adverse reactions occurred. 753 Infecton images were produced. 517 of these were positive, including 38 false positives, 226 of these were negative of which 162 were true negatives and 64 were false negatives. 10 scans were indeterminate. Thus, Infecton has a sensitivity of 88.2% and a specificity of 81% for detecting infective foci. For microbiologically and CDC proven cases the sensitivity and specificity were 93.3% and 100% respectively. Conclusion: Infecton imaging has major advantages over well-established radiolabelled imaging techniques.The high specificity enables a +ve image to strongly support a diagnosis of bacterial infection. Studies are underway to determine whether serial imaging can be used to follow the response to infection and antimicrobial chemotherapy. An agent able to predict the requirement for and the duration of antibiotic treatment will not only decrease cost but also contribute to the fight against antimicrobial resistance.KEYWORDS: Bacterial Infections; Imaging; Infection

Publication Types:

• Meeting Abstracts

Keywords:

• Anti-Infective Agents
• Bacteria
• Bacterial Infections
• Ciprofloxacin
• Evaluation Studies
• Humans
• Organotechnetium Compounds
• Radiopharmaceuticals
• Sensitivity and Specificity
• Technetium Tc 99m ciprofloxacin
• methods

Other ID:

• GWAIDS0011469

UI: 102248967

From Meeting Abstracts