FINEGOLD SM, WYNNE B, ROSE FV, WEXLER HM, BERKOWITZ E, JOUSIMIES-SOMER H, JAKIELASZEK C, FLYNN MJ; Interscience Conference on Antimicrobial Agents and Chemotherapy.
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2000 Sep 17-20; 40: 494.
VA Med. Ctr., West Los Angeles and UCLA Sch. of Med., Los Angeles, CA
Maxillary sinusitis (MS) affects numerous adults. An evaluation of amoxicillin/clavulanate 875/125 mg bid in complicated MS was done with an open-label, non-comparative, multi-center study of adults, aged 18 to 77 years. Cultures were obtained by puncture via canine fossa or lateral wall of nasal cavity prior to therapy. Pts were treated for 14 to 28 days and monitored by on-therapy-telephoning, end-of-therapy (EOT) and follow-up (F/U) visits. Of 190 enrolled pts, 89 were clinically evaluable at EOT, 80 (90%) of whom were improved or cured, while at F/U 67 pts were clinically evaluable, 52 (78%) of whom were persistent cures. Of 114 culture-positive specimens, 47% grew aerobes only, 15% anaerobes only, and 38% grew both at baseline in the intent-to-treat population. Of the 109 (60%) aerobes and 73 (40%) anaerobes isolated at baseline in clinically evaluable patients at F/U, 80% of aerobes and 75% of anaerobes were eradicated based upon clinical outcome. Recurrences associated with anaerobes were twice as frequent as with aerobes when counts were >/= 10[3]/mL; however, overall failure rates were <1% and <8%, respectively. Aerobic gram-positive organisms (mostly streptococci) represented 41% of all strains. Anaerobes included Actinomyces, Fusobacterium, Peptostreptococcus, Prevotella, Propionibacterium, and Veillonella. Organisms recovered in pure culture included M. catarrhalis, Abiotrophia, S. sanguis, S. aureus, S. pneumoniae, viridans streptococci, H. influenzae, and S. maltophilia. Of 190 pts, 77 had an adverse experience (AE); most were mild (44%) or moderate (37%) in severity. Only 4.7% of pts were withdrawn due to AEs, mostly gastrointestinal in nature. Amoxicillin/clavulanate was highly efficacious for therapy of MS caused by aerobic and/or anaerobic organisms.KEYWORDS: Amoxicillin/clavulanate; Anaerobes; Sinusitis
Publication Types:
Keywords:
- Adult
- Amoxicillin
- Bacteria, Aerobic
- Bacteria, Anaerobic
- Clavulanic Acid
- Fusobacterium
- Haemophilus influenzae
- Humans
- Maxillary Sinusitis
- Prevotella
- Sinusitis
- therapy
Other ID:
UI: 102249025
From Meeting Abstracts