Corti ME, Villafane Fioti MF, Schtirbu RB, Yampolsky CG; International Conference on AIDS.

Int Conf AIDS. 2002 Jul 7-12; 14: abstract no. B10312.

F.J.Muniz Infectious Diseases Hospital, Buenos Aires, Argentina

BACKGROUND: Primary central nervous system lymphomas (PCNSL) occurs frequently in patients with AIDS and is the most common neoplasm in these patients. METHODS: We reviewed the clinical manifestations, neuroimaging findings, diagnosis methods, histologic characteristics, detection of DNA-EBV by PCR and outcome of 14 HIV/AIDS patients attended between 1995-2001. RESULTS: The global incidence of PCNSL was 1.6%; 78.6% of patients were men. The mean of age was 32.6 years and the mean of CD4 T counts was 39 cells/uL. The most frequent clinical findings were focal deficits and seizures.. On CT scans and MRI images, PCNSL showed as single and large (>2,5 cm) lesions in 71.4% patients and were multiple at presentation in 28.6%. The totality of lesions were associated with mass effect and surrounding edema. The most common locations were periventricular white matter, basal ganglia, thalamus and caudate nucleus. One patient presented multiple lesions located at the cerebellum and brain stem; another had a single lesion placed at left cerebellum hemisphere; finally, 12 patients had mass lesions situated at the brain hemispheres. Diagnosis methods included: stereotactic biopsy (50%), autopsy studies (28.6%) and clinical manifestations and neuroimaging findings, including SPECT (21.4%). In 5 patients we carried out the detection of DNA-EBV by PCR of brain smears; all of them were positive. Histological studies seemed that all tumors were lymphomas of high-grade and type B fenotype. The mean of survival after specific diagnosis was 105 days. CONCLUSIONS: Early stereotactic biopsy to achieve specific diagnosis is essential. PCNSL were associated with a poor prognosis and a shorter survival in this cohort of patients.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Biopsy
• Brain
• Brain Edema
• CD4 Lymphocyte Count
• Central Nervous System Neoplasms
• HIV Infections
• Herpesvirus 4, Human
• Humans
• Incidence
• Lymphoma
• Lymphoma, B-Cell
• Lymphoma, T-Cell
• Magnetic Resonance Imaging
• Male
• Polymerase Chain Reaction
• Tomography, X-Ray Computed
• diagnosis
• radiography

Other ID:

• GWAIDS0015932

UI: 102253430

From Meeting Abstracts