Wilkin T, Palmer S, Brudney K, Chiasson M, Wright T; Conference on Retroviruses and Opportunistic Infections.

Abstr 10th Conf Retrovir Oppor Infect Feb 10 14 2003 Hynes Conv Cent Boston Mass USA Conf Retrovir Oppor Infect 10th 2003 Boston Mass. 2003 Feb 10-14; 10: abstract no. 819.

Weill Med Coll of Cornell Univ, New York, NY

BACKGROUND: Previous studies of HIV+ men have demonstrated a high rate of anal SIL -- a precursor to anal carcinoma, but they included predominantly white men who have sex with men and men not on effective Antiretroviral Therapy (ART). We examined the prevalence of anal Squamous Intraepithelial Lesions (SIL) and high-risk HPV in a group of HIV+ men including men of color, men with and without a history of receptive anal intercourse (RAI), and those on and off effective ART.METHODS: Cross-sectional study in ID clinic serving mainly Latino and African Americans. Participants were evaluated with a sexual questionnaire, Digene Hybrid Capture II HPV DNA assay for high-risk types of HPV, liquid-based cytology, and anal colposcopy with biopsy of visible lesions. Predictors of anal HPV, abnormal cytology, and anal SIL on biopsy were determined by chi square test, and logistic regression.RESULTS: Ninety-two (92) men were screened for anal HPV and anal SIL; 53% Latino, 36% African-American; 40% denied RAI ever, 82% were on ART, and 61% had HIV RNA < 400 copies/ml. The nadir CD4 count of those on ART (63 cells/mm3) was lower than those not on ART (290 cells/mm3), p < 0.001. Overall 47% had abnormal cytology: 18% atypical squamous cells of uncertain significance, 24% low grade SIL and 6% high grade SIL. Forty percent (40%) had abnormal histology: 31% low grade SIL, 9% high grade SIL. [table: see text]CONCLUSIONS: Although anal high-risk HPV infections and SIL in HIV+ men are associated with a history of RAI, both conditions are commonly identified in HIV+ men who deny RAI. Using multivariate analysis both nadir CD4 and no current ART use are associated with anal SIL but not with detection of anal HPV.

Publication Types:

• Meeting Abstracts

Keywords:

• AIDS Vaccines
• Acquired Immunodeficiency Syndrome
• Anal Canal
• Anti-HIV Agents
• Antiretroviral Therapy, Highly Active
• Anus Diseases
• Anus Neoplasms
• CD4 Lymphocyte Count
• Carcinoma in Situ
• Cross-Sectional Studies
• HIV
• HIV Infections
• HIV Seropositivity
• Humans
• Male
• Neoplasms, Squamous Cell
• Papillomaviridae
• Prevalence
• drug therapy
• therapy

Other ID:

• GWAIDS0021845

UI: 102261469

From Meeting Abstracts