Fortin C, Rouleau D, Trepanier JM, Ghattas G, Vezina S, Cote P, Cote B, Poliquin M, MacLeod JD, Aho J, Allaire G, Kornegay J, Franco E, Coutlee F; IAS Conference on HIV Pathogenesis and Treatment (2nd : 2003 : Paris, France).
Antivir Ther. 2003; 8 (Suppl.1): abstract no. 941.
CHUM de l'Universite de Montreal, Montreal, Canada
OBJECTIVES: HIV-seropositive men are at increased risk for anal intraepithelial lesions (AIN) and infection by human papillomaviruses (HPV). The spectrum of recently described genital HPV types in anal infection in HIV-infected men is described here. METHODS: Men infected by HIV starting HAART were recruited consecutively and followed 6-monthly. Anal exfoliated cells were obtained for cytology and HPV detection. Thirty-eight genital HPV types were identified with PCR using PGMY primers. Biopsies were performed during high-resolution anoscopy. RESULTS: 135 (97.8%) of 138 anal samples from 113 men contained HPV DNA. The most frequent genotypes identified were types 16 (58 men), 6 (47), 52 (35), 45 (34) and 18 (30). Of the newer types studied, four were detected in at least 20 specimens (types 61, 70, 73, 84). HPV-57 was the only type undetected in our cohort. Of the 90 men with anoscopy results, 36 were normal, 36 had AIN I and 18 had AIN II-III on anal biopsies. HPV-16 was detected in 12 (33%) of 36 normal men versus 11 (61%) of 18 men with AIN II-III (P=0.05). All 18 men with high-grade AIN were infected with at least one oncogenic HPV type. A greater number of oncogenic types were identified in specimens from men with high-grade AIN (median of 4, range of 0-9) that normal men (median of 2,5, range of 0-6) (P=0.04, Mann-Whitney). CONCLUSIONS: Anal HPV infection was nearly universal in men infected with HIV and often caused by multiple types. High-grade AIN contained a greater burden of HPV types.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Anal Canal
- Anus Diseases
- Anus Neoplasms
- HIV Infections
- HIV Seropositivity
- Humans
- Male
- Papillomaviridae
Other ID:
UI: 102263219
From Meeting Abstracts