Pradier C, Bentz L, Spire B, Tourette-Turgis C, Morin M, Fuzibet JG, Pesce A, Dellamonica P, Moatti JP; Conference on Retroviruses and Opportunistic Infections.
9th Conf Retrovir Oppor Infect Feb 24 28 2002 Wash State Conv Trade Cent Seattle Wash Conf Retrovir Oppor Infect 9th 2002 Seattle Wash. 2002 Feb 24-28; 9: abstract no. 541-T.
INSERM U379, Marseilles
BACKGROUND: The objective was to evaluate the impact of an intervention for improving adherence to highly active antiretroviral therapies (HAART) in HIV-infected patients. Method: 244 patients were included in a prospective, controlled, randomised trial comparing a group who received a counseling intervention in addition to ordinary clinical follow-up (n=123) vs a control (n=121). Inclusion criteria were patients receiving HAART for at least 1 month who attended a medical follow-up consultation between September and December 1999. Patients in the intervention group received 3 individual counseling sessions about HAART regimens by specially trained nurses. The main outcome measures were proportions of patients achieving 100% adherence at 6-month follow-up (M6) and evolution in viral load between inclusion (M0) and M6.RESULTS: Between M0 and M6, HIV-1 RNA significantly decreased in the 123 patients of the intervention group (mean difference = -0.22 log[I; 0.86], p=0.013) while it increased (+0.12 log[I; 0.90], p=0.14) in the 121 patients of the control. However, the proportion of patients with HIV-1 RNA < 40 copies/mL remained similar in both groups. Among the 202 patients with available data on adherence, the proportion of 100% adherent patients was similar in both groups at M0 (58% vs 63%, p=0.59) but became higher in the intervention group at M6 (75% vs 61%, p=0.04).CONCLUSIONS:The study brings evidence of the feasibility and efficacy of a counseling intervention to increase adherence to HAART that could be easily implemented in most clinical settings.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- Counseling
- HIV Infections
- Humans
- Prospective Studies
- Research Design
- Viral Load
- methods
- psychology
Other ID:
UI: 102263994
From Meeting Abstracts