LE GALLOU F, CHARRIEAU M, MORIN O; Interscience Conference on Antimicrobial Agents and Chemotherapy (43rd: 2003: Chicago, Ill.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2003 Sep 14-17; 43: abstract no. K-561.
Microbiol. Lab., Univ. Hosp., Nantes, France.
BACKGROUND: Aspergillus species (Asp) are described pathogens in immunocompromised patients and building work on hospital sites is associated with outbreaks of aspergillosis. A prospective study was conducted in order to evaluate the fungal impact on high-risk units (without high efficiency particulate air filtration) of EW adjacent to our hospital for a new building. METHODS: Air sampling (AS) was carried out to monitor the Asp spore load in the air in one external and five internal sites (adults and pediactric oncology, neonatalogy, renal transplant units). Data were collected weekly from November 2000 to September 2001 (27 weeks before EW and 15 weeks during EW) including clinical mycology reports, AD consumption for invasive aspergillosis treatment (amphotericin B, itraconazole), and weather conditions at the time of AS. RESULTS: EW caused a significant increase in the Asp (3.94 vs 2.41 mean Colony Forming Unit (CFU)/week, p=0.003) and A. fumigatus (2.94 vs 1.23 mean CFU/week, p=0.0002) concentration in the internal hospital sites, especially when hygrometry > 87%, wind speed >12Km/h and temperature <12degreesC. Wind direction from EW to hospital was correlated with an increase of A.niger and A.flavus. There was no relationship between EW and AD consumption, except for liposomal amphotericin B in pediatric oncology (30 vs 1.7 units/week, p<10-6). A. fumigatus was isolated by culture from 11 patients samples and 10 patients had a positive reseach for Asp antigen in blood, without statistical association with EW. CONCLUSIONS: This study showed the increase of Asp spore load in the air during EW in high-risk units without air filtration, underscoring the importance of additionnal measures to prevent aspergillosis (as sealing of windows, controlling dust) in such conditions. The value of clinical mycology reports and AD comsumption as surveillance parameters is questionable and must be validated with a prospective survey of invasive aspergillosis.
Publication Types:
Keywords:
- Adult
- Air
- Air Microbiology
- Air Pollution, Indoor
- Antifungal Agents
- Aspergillosis
- Aspergillus
- Child
- Dust
- Fungi
- Humans
- Immunocompromised Host
- Longitudinal Studies
- Mycology
- Niger
- Prospective Studies
- immunology
- microbiology
Other ID:
UI: 102265715
From Meeting Abstracts