DRUGEON HB, JUVIN M, MONIOT-VILLE N; Interscience Conference on Antimicrobial Agents and Chemotherapy (43rd: 2003: Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2003 Sep 14-17; 43: abstract no. E-1527.

CHU Nantes, Nantes, France.

BACKGROUND: This first year of this 3 year surveillance study was initiated to monitor the in vitro activity of telithromycin (TEL) and other antibiotics against SP. METHODS: Strains were collected in 42 centres. MICs of penicillin (PEN), erythromycin (ERY), amoxicillin (AMX), cefuroxime (CFM), clarithromycin (CLA) and TEL were determined by broth microdilution. Susceptibility rates were calculated according to the Comite de l'Antibiogramme de la Societe Francaise de Microbiologie recommendations. ErmB and mefA genes were detected by PCR among ERY resistant strains. Quality control was performed with 3 SP strains (susceptible, ermB, mefA). RESULTS: From a total of 965 strains isolated, 49.8%, 3.7% and 46.5% were susceptible (S), intermediate (I) and resistant (R) to ERY and 45.8%, 19.7% and 34.5% were PEN S, I and R, respectively. MIC50/90 (mg/L) - % of susceptibility were the following: AMX: Overall (n=965): 0.06/2-63.4; PEN S (n=442): 0.015/0.03-100; PEN I (n=190): 0.25/1-78.4; PEN R (n=333): 2/2-32.5; ERY S (n=480): 0.015/0.5-91; ERY IR (n=485): 1/2-36.1. CFM: Overall: 0.5/8-53.6; PEN S: 0.03/0.25-99.5; PEN I: 2/4-40.5; PEN R: 4/8-14.7; ERY S: 0.03/1-88.3; ERY IR: 4/8-19.2. CLA: Overall: 1/32-52; PEN S: 0.03/4 - 89.1; PEN I: 32/32-32.6; PEN R: 32/32-20.6; ERY S: 0.03/0.06-99.8; ERY IR: 32/32-4.7. TEL: Overall: 0.015/0.125-98.7; PEN S: 0.015/0.015-100; PEN I: 0.015/0.06-97.9; PEN R: 0.03/0.25-97.5; ERY S: 0.015/0.015-100; ERY IR: 0.03/0.25-97.3. No strain was resistant to TEL. Among ERY IR strains, 473 were ermB, 6 were mefA and 2 had both genes. CONCLUSIONS: This study confirms the high prevalence of macrolide and betalactam resistance among SP strains isolated from adult RTIs in France and the importance of cross-resistance between betalactams and macrolides. TEL has a strong activity against SP, including betalactam and macrolide-resistant strains.

Publication Types:

• Meeting Abstracts

Keywords:

• Adult
• Anti-Bacterial Agents
• Antigens, Bacterial
• Clarithromycin
• DNA-Binding Proteins
• Erythromycin
• France
• Humans
• In Vitro
• Ketolides
• Macrolides
• Microbial Sensitivity Tests
• Penicillins
• Repressor Proteins
• Respiratory Tract Infections
• Streptococcus pneumoniae
• immunology
• telithromycin

Other ID:

• GWAIDS0026303

UI: 102265927

From Meeting Abstracts