SYROGIANNOPOULOS GA, GRIVEA IN, BERATIS NG; HELLENIC ANTIBIOTIC-RESISTANT PATHOGENS (HARP) STUDY GROUP; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd: 2002: San Diego, Calif).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. G-436.
Univ. of Patras, Med. Sch., Patras, Greece
BACKGROUND: Amoxicillin once-daily for 10 days has been suggested as an effective treatment for Group A streptococcal tonsillopharyngitis (GAS-TP) with potential for better compliance. METHODS: In an ongoing, open-label study of the HARP Study Group, initiated in September '01, children (aged 2-16 yrs) with GAS-TP were randomly assigned to receive amoxicillin/clavulanate (A/C) once-daily (30.6/4.4 mg/kg qd; maximum dose 1,200/171 mg qd) or twice-daily (43.8/6.2 mg/kg/day bid; maximum dose 875/125 mg bid) for 7 days. Post-treatment clinical evaluation and throat culture (TC) were performed at 4-8 (V[2]) and 21-28 (V[3]) days. RESULTS: On 23 April '02 there were 194 children with GAS-TP treated per protocol. The 194 GAS isolates had A/C MIC range: 0.016-0.064 mcg/ml and MIC[90]: 0.032 mcg/ml. The twice-daily A/C regimen had clinical success at V[2] and V[3] in 98% (94/96) and 95% (91/96) of the children, respectively. In the same regimen, eradication of GAS from TC at V[2] and V[3] was observed in 92% (88/96) and 89% (81/91) of the children treated, respectively. The clinical and bacteriological efficacy of the once-daily A/C regimen in children aged <6 and >/= 6 yrs is shown in the following table. CONCLUSIONS: The once-daily A/C (30.6/4.4 mg/kg qd) 7-day regimen had suboptimal bacteriological efficacy. Once-daily A/C had better clinical and bacteriological efficacy in children aged >/= 6 yrs than in children <6 yrs. This difference was more prominent at the 21-28 day post-treatment visit, when the bacteriological efficacy in the <6 yrs age-group was significantly lower than that found in the >/= 6 yrs group.
Publication Types:
Keywords:
- Amoxicillin
- Child
- Clavulanic Acid
- Humans
- Periodicity
- Streptococcus
- Streptococcus pneumoniae
- Streptococcus pyogenes
Other ID:
UI: 102268030
From Meeting Abstracts