MACHADO AR, SELIGMAN B, KUCHENBECKER R, KONKEWICZ LR, KUPLICH NN; Interscience Conference on Antimicrobial Agents and Chemotherapy (42nd : 2002 : San Diego, Calif.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2002 Sep 27-30; 42: abstract no. K-448.

Hospital de Clinicas De Porto Alegre, Porto Alegre, Brazil.

BACKGROUND: Necrotizing enterocolitis (NEC) is a major cause of mortality in neonates. There are potential factors related to the disease, but no isolated risk factor is described. METHODS: Retrospective case-control study to investigate antenatal, demographic and postnatal variables in a neonatal intensive care unit outbreak of NEC, from April to May, 2001. Eleven consecutive infants with NEC and three controls each, matched for weight at delivery were compared. Information about prenatal relevant obstetric and neonatal variables, as well as important neonatal outcomes and data about breast feeding, invasive procedures and antibiotic use was obtained from case notes. RESULTS: Mean birth weight in cases and controls was, respectively, 1,694 g (min 375, max 2,880), and 1,585 g (min 630, max 2,785). Deaths were more common in cases (Odds ratio: 8.0; 95%CI 1.1-62.8) - Fischer's Chi-square. Four variables were statistically associated with NEC in the univariate analysis: antenatal maternal infection, medical complications during labor, apgar values less than 8 in the fifth minute, and enteral formula feeding during neonatal intensive care unit hospitalization. Logistic regression demonstrated enteral formula feeding as a risk factor for NEC (OR:11.3; 95%CI 0.9-140.3). Simultaneously feeding with enteral formula and breast milk was associated with reduced risk (OR: 0.1; 95% CI 0.01-0.9). A low number of infants received exclusive breast feeding, precluding analysis. CONCLUSIONS: Enteral formula feeding may represent a risk factor for NEC in neonates. Simultaneous feeding with breast milk and enteral formula may represent a small protection to NEC, and be surrogate marker of less compromised neonates.

Publication Types:

• Meeting Abstracts

Keywords:

• Birth Weight
• Breast Feeding
• Case-Control Studies
• Disease Outbreaks
• Enterocolitis, Necrotizing
• Humans
• Infant
• Infant, Low Birth Weight
• Infant, Newborn
• Infant, Premature
• Infant, Very Low Birth Weight
• Intensive Care Units, Neonatal
• Logistic Models
• Milk, Human
• Odds Ratio
• Risk Factors

Other ID:

• GWAIDS0028444

UI: 102268068

From Meeting Abstracts