MULLER-SERIEYS C, DELATOUR F, LEMAITRE F, POIRIER I, PANHARD X, TCHIMICHKIAN F, SAFRAN C, MENTRE F, ANDREMONT A, CREMIEUX A; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. A-637.

Microbiol. Bichat-Claude Bernard Hosp., Paris, France

BACKGROUND: The ecological impact of antibiotic treatments (Rx) on the commensal flora is of increasing concern. Telithromycin (T), a ketolide, is effective against pathogens involved in respiratory tract infections. METHODS: We compared in a randomized open study, the effects of oral T (800 mg, once daily) versus AMX/CA (1g/125mg, t.i.d.) for 7 days, on the intestinal, skin and oropharyngeal microflora of two groups of 25 healthy male volunteers (age 28+/-6.6 yr). Fecal, cutaneous and pharyngeal samples were collected before Rx (D-1), and after the end of Rx (D8, D14, D21, D45), and blindly analyzed. RESULTS: Stool yeast counts increased significantly (+ 0.8 Log[10] CFU/g, P< 0.0004) in all patients, regardless of Rx, with no difference between the 2 groups on D8. They decreased slowly thereafter, with no difference in the AUCs. Clostridium difficile were detected in the stools of 4/25 patients treated with AMX/CA, associated with digestive disorders in 2. Among skin flora, coagulase negative staphyloccoci (CNS) counts remained stable and no emergence of resistant CNS or resistant S. aureus strains were observed on D8. In the oropharynx, AMX/CA significantly decreased streptococci (P< 0.003). Resistant streptococci to both antibiotics were significantly more frequent after AMX/CA than T (P< 0.008). Colonization by S. pneumoniae, H. influenzae or M. catharralis did not differ significantly between groups. CONCLUSIONS: The impact of T was less important than that of AMX/CA on the oropharyngeal flora. Unlike AMX/CA, T did not lead to Clostridium difficile colonization.

Publication Types:

• Meeting Abstracts

Keywords:

• Amoxicillin
• Anti-Bacterial Agents
• Clavulanic Acid
• Feces
• Haemophilus influenzae
• Humans
• Intestines
• Ketolides
• Macrolides
• Male
• Oropharynx
• Pneumonia
• Respiratory Tract Infections
• Skin
• Skin Diseases, Bacterial
• telithromycin

Other ID:

• GWAIDS0028887

UI: 102268519

From Meeting Abstracts