ULRICH R; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. 1287.
Abbott Lab., Abbott Park, IL
Genomic technologies are having a major impact on many areas of drug discovery and development. Of these technologies, analysis of gene expression during a toxic response (toxicogenomics) using microarrays and related technologies now holds the promise of rapidly identifying toxicological pathways and liabilities. Microarrays can be used to differentiate or cluster individual compound effects (expression profiling), and discrete gene changes may reveal a mechanistic basis for toxicity. Profiling can also identify markers for assay development. Using expression profiling of rat liver, several diverse, well-characterized hepatotoxic drugs and chemicals have been evaluated for (and can be distinguished by) gene expression profiles. By comparing new compounds against this compendium it is possible to rapidly identify potential liabilities and to derive an understanding of compound side effects. Towards this we have also examined several antiinfective agents, including both antibacterials and antivirals, for effects on liver gene expression and function. Expression profiles are combined with other biological markers (including histopathology and clinical chemistry) for a more complete analysis if the cellular effects of drugs. The potential impact of gene expression profiling on our understanding of adverse responses is tempered by the difficulties in interpreting large-scale expressional data and the lack of sufficient databases for comprehensive comparisons. None-the-less, over the next several years these new tools will greatly enhance both the speed and accuracy of drug safety evaluation and will help direct the discovery of safer drugs.
Publication Types:
Keywords:
- Animals
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antiviral Agents
- Biological Markers
- Gene Expression
- Gene Expression Profiling
- Gene Expression Regulation
- Liver
- Pharmaceutical Preparations
- Rats
- Toxicogenetics
- genetics
Other ID:
UI: 102268854
From Meeting Abstracts