AMIN AN, MCKEOUGH M, DOUGLAS M, SPRUANCE S; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).
Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. H-1899.
Novactyl, Inc., St. Louis, MO
BACKGROUND: Fusaric acid (FA) is a pyridine carboxylate that has anti-hypertensive effects, inhibits B-hydroxylases, and has anti-viral properties against HSV-1 and -2. Acyclovir ointment ([AO], 5% acyclovir ointment, GlaxoWellcome, RTP, NC) is approved for the episodic treatment of herpes labialis in immunocompromised persons in the United States. We compared the two directly in a guinea pig model of primary HSV-1 infection. METHODS: 5% fusaric acid cream (FAC) was applied 2x/day for three days and acyclovir ointment (AO) 4x/day. (Irritation precluded more frequent dosing). Four sites on the backs of female Hartley out bred guinea pigs were infected with HSV-1 by multiple punctures with a vaccination device (Day 0). Animals were evaluated for efficacy on Day 4 by measurements of lesion number, lesion area and virus titer. The activity was compared to vehicle controls (VEH[FAC] and VEH[AO]). RESULTS: FAC and AO exhibited statistically significant reductions in virus titer and total lesion area. Only FAC achieved a statistically significant reduction in lesion number. [table: see text] FAC reduced virus titer, lesion area, and # of lesions by 56%, 39%, and 26% respectively (p = 0.03, 0.01, and 0.008 respectively). AO reduced virus titer, lesion area, and # of lesions by 60%, 23%, and 2% respectively (p = 0.006, 0.003, and 0.27 respectively). CONCLUSION: It may be worthwhile to investigate the clinical efficacy of fusaric acid cream preparations in the treatment of recurrent herpes labialis.
Publication Types:
Keywords:
- Acyclovir
- Animals
- Communicable Diseases
- Female
- Guinea Pigs
- Herpes Labialis
- Herpesvirus 1, Human
- Infection
- Ointments
- Skin
- Skin Absorption
- Skin Diseases
- United States
- Vehicles
- drug therapy
- therapy
Other ID:
UI: 102269304
From Meeting Abstracts