KIMURA T, SHIMADA M, NONOYAMA M, SATOU M, NOWATARI M, MATSUURA N, SUNAKAWA K, KUBO H; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. A-947.

Kitasato Univ. Hosp., Sagamihara Kanagawa, Japan

BACKGROUND: PPK might help to determine the adequate dosage regimen of antibiotics in neonates with varying maturation. The study was conducted on three types of antibiotics, an aminoglycoside ABK, a glycopeptide VCM, and a carbapenem PAPM. METHODS: A total of 83 neonates were allocated to ABK (41), VCM (19) and PAPM (23). The post-conception age (PCA) of the subjects were 24.1 - 48.4 weeks and their body weight (BW) ranged 458 - 5200g. Antibiotics was infused over a period of 30 - 60 min and the blood samples were obtained prior to, at 1 - 2 hr, and at 6 hr after the infusion. One compartment open model with first-order elimination and the NONMEM program was applied for PPK analyses. RESULTS: In the fitting process, the significantly fixed effects related to clearance (CL) were PCA, postnatal age (PNA), gestational age (GA), BW and serum creatinine (Scr), and that related to the distribution volume (Vd) was BW. The final formulas for the PPK parameters were as follows: CLABK = 0.0238xBW/Scr (PCA<33), 0.0367xBW/Scr (PCA=>33), VdABK = 0.54 (L/kg): CLVCM = 0.0250xBW/Scr (PCA<34), 0.0323xBW/Scr (PCA=>34), VdVCM = 0.66 (L/kg): CLPAPM = 0.0832 (PCA<33), 0.179xBW (PCA=>33) and VdPAPM = 0.53 (L/kg). When evaluated each CL by the NONMEM, we found that the mean CL of the subjects with PCA < 33 to 34 was significantly smaller than those with a PCA of 33 to 34, and the CL showed a logarithmic increase with PCA. CONCLUSION: Many antibiotics are excreted by glomerular filtration (GF), and the maturation of GF is the most important factor for estimating the antibiotics CL. Many studies indicated the developmental changes in the renal function of neonates with PCA. We should consider the value of PCA, serum creatinine and BW when determining the initial dosing regimen of antibiotics in neonates.

Publication Types:

• Meeting Abstracts

Keywords:

• Aminoglycosides
• Anti-Bacterial Agents
• Creatinine
• Dibekacin
• Gestational Age
• Glomerular Filtration Rate
• Humans
• Infant, Newborn
• Infant, Premature
• Population
• Population Groups
• Thienamycins
• Vancomycin
• habekacin
• panipenem
• pharmacokinetics

Other ID:

• GWAIDS0029774

UI: 102269406

From Meeting Abstracts