GOLAN Y, JACOBUS NV, MCDERMOTT AL, SUPRAN S, HECHT DW, GOLDSTEIN E, VENEZIA R, HARRELL L, JENKINS S, RIHS J, PIERSON C, GORBACH SL, FINEGOLD S, SNYDMAN DR; Interscience Conference on Antimicrobial Agents and Chemotherapy (41st : 2001 : Chicago, Ill.).

Abstr Intersci Conf Antimicrob Agents Chemother Intersci Conf Antimicrob Agents Chemother. 2001 Dec 16-19; 41: abstract no. K-1209.

New England Medical Center, Boston, MA

BACKGROUND: Among the BSp, Bacteroides fragilis (Bf) is considered to be the most virulent, the least resistant to antibiotics, and the most common in clinical cultures. Over the last 2 decades, antibiotic use resulted in a change in the epidemiology of many bacterial species, as resistant species have replaced susceptible ones. We describe the changing epidemiology of BSp in the US. METHODS: Bacteroides isolates from clinical specimens in 13 US hospitals during the years 1995-00 were sent to the Tufts anaerobes lab as part of an ongoing surveillance. Species-specific isolation rates were correlated with year of isolation, hospital, and site. Findings were compared to 1984-5. RESULTS: 3045 isolates were analyzed. The overall rate of Bf isolation decreased from 63% in 1984-5 to 53% in 1995-00 (p<0.001). Analysis by site of isolation revealed a decrease from 59% in 1984-5 to 46% in 1995-00 for intra abdominal infections (p<0.001) and from 71% to 57% for blood isolates (p=0.002). No significant decrease was observed for soft tissue, bone, and respiratory tract isolates. Bf remained the most antibiotic-susceptible BSp; nevertheless, its resistance to multiple antibiotics has significantly increased. Rates of clindamycin resistance increased from 6.7% in 1984-5 to 16% in 1995-00 (p<0.001). Analysis of Bf isolation rates by hospital revealed a consistent decrease in the rate of Bf isolation between 1995 and 2000. CONCLUSIONS: Isolation of non-fragilis Bacteroides had markedly increased over the last 15 years. These species are now the most common anaerobes in intra abdominal infections. They exhibit increased antibiotic resistance that may result in treatment failures.

Publication Types:

• Meeting Abstracts

Keywords:

• Anti-Bacterial Agents
• Bacteria, Anaerobic
• Bacteroides
• Bacteroides Infections
• Bacteroides fragilis
• Clindamycin
• Infection
• epidemiology

Other ID:

• GWAIDS0029861

UI: 102269493

From Meeting Abstracts