Del Amo J, Perez-Hoyos S, Quintana M, Ruiz I, Cisneros JM, Ferreros I, Barrasa A, Garcia de Olalla P, Perez C, Hernandez I; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).

Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. C11386.

Gemes. University Miguel Hernandez, Alicante, Spain

Background: Highly Active Antiretroviral Therapy (HAART) reduces AIDS related mortality but the changes in non-AIDS mortality have been less studied. This paper examines the impact of calendar period on progression toAIDS, AIDS and non-AIDS related mortality (liver disease, haemorrhagic complications and other causes) in HIV-infected haemophilics. Methods: HIV seroconversion was estimated using mathematical techniques for interval censored data from 1979-1985. Cumulative risk of AIDS and death was calculated by extended Kaplan-Meier allowing for late entry and PoissonRegression to estimate AIDS and death rates in 2-years periods from 1982 to2001 allowing for competing risks. Findings: Median times to AIDS and death in 609 subjects were 11.2 and 13.2 years respectively and were strongly age dependent (p<0.001). By December2001, 78% were receiving HAART. Risk of AIDS and all-cause mortality decreased by 87% (RR 0.13 95%CI:0.05-0.31) and 79% (RR 0.21 95%CI:0.12-0.38) respectively in 1998-2001 compared to 1996-97. Reductions in mortality were not statistically significant in haemophilics infected over 26 years of age. In 1998-2001, 37% of deaths were AIDS-related and 37% liver disease-related, representing an 89% (RR 0.11 95%CI:0.04-0.27) and 45% (RR 0.5495%CI:0.16-1.76) decrease in AIDS-related and liver-related deaths respectively. Interpretation: Important reductions in AIDS and all-cause mortality rates are observed in 1998-2001 but survival improvements are only significant forAIDS-related deaths and for haemophilics infected under 26 years of age. Liver disease accounts for an increasing proportion of deaths but no increase in death rates neither from this pathology nor from other causes has so far been observed.

Publication Types:

• Meeting Abstracts

Keywords:

• Acquired Immunodeficiency Syndrome
• Antiretroviral Therapy, Highly Active
• Disease Progression
• HIV Infections
• HIV Seropositivity
• Humans
• mortality

Other ID:

• GWAIDS0033109

UI: 102277323

From Meeting Abstracts