Hartmann M, Boit R, Jenssen JS; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. ThPeA6942.
University, Heidelberg, Germany
Background: The prevalence of Mycoplasma genitalium and Ureaplasma urealyticum in patients without urethritis among HIV-infected patients is not yet established. Some investigators suggest that the detection in AIDS patients increases up to 56% and over 10% in HIV positive patients. Others found a correlation between infection with Mycoplasma genitalium and enhanced HIV transmission. Methods: Polymerase chain reaction (PCR) for Mycoplasma genitalium was performed from urine and urethral, cervical, rectal and oral swabs from 61 HIV-1 positive patients without urethral symptoms. The samples were also examined for Mycoplasma hominis and Ureaplasma urealyticum by culture and Chlamydia trachomatis by PCR. Results: Ureaplasma urealyticum was detected in 1 patient and Mycoplasma genitalium in 3 (5%) out of the 61 HIV-infected patients. Although the number is low there was no association between number of CD4-cell count, HIV viral load, antiretroviral therapy, CDC-classification (C3) and the detection of Mycoplasma genitalium. Positive probes were mostly urine specimen, urethral and rectal swabs. Conclusion Our data confirm that the frequency of Mycoplasma genitalium and Ureaplasma urealyticum infection in HIV positive patients was comparable to that observed in HIV negative subjects and does not correlate with the clinical stage of HIV infection. The results do not support that Mycoplasma genitalium is a cofactor of HIV transmission.
Publication Types:
Keywords:
- Acquired Immunodeficiency Syndrome
- Chlamydia trachomatis
- HIV Infections
- HIV Seropositivity
- HIV-1
- Humans
- Male
- Mycoplasma genitalium
- Mycoplasma hominis
- Polymerase Chain Reaction
- Prevalence
- Ureaplasma Infections
- Ureaplasma urealyticum
- Urethra
- Urethritis
Other ID:
UI: 102280726
From Meeting Abstracts