Rahman M, Hoque M, Mamun SA, Rahman ZA, Sultan Z; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).
Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. ThPeC7345.
Dhaka Medical College Hospital, Dhaka, Bangladesh
Background: The emergence of resistance to antimicrobial agents in Neisseria gonorrhoeae is a major obstacle in the control of gonorrhea. The study was conducted to asses cure rate with single-dose oral Azithromycin and Azithromycin and cefixime for treatment of gonococcal urethritis. Materials and methods: A randomized control study was conducted among patients attending with complains of urethral discharge in Skin & VD Department of Dhaka Medical College Hospital, Dhaka, Bangladesh during March 2002 to July 2003. Subjects were randomized to either azithromycin (1gm single oral dose) or azithromycin (1gm single oral dose) and cefixime (400 mg single oral dose) treatment group. Urethral swab and urine sample was collected from each subject after enrollment and was asked for a follow up visit after seven day. Diagnosis of gonococcal infection was made by culture of urethral swab during first and follow up visit. Diagnosis Chlamydia trachomatis was made by PCR. Pre and post treatment isolates were analyzed by serotyping using monoclonal antibodies (Boule diagnostics AB, Sweden) and genotyping to differentiate between treatment failure and re-infection. Results: A total of 291 patients with complaints of urethral discharge were enrolled in the study and of them 182 culture positive cases available for follow up was evaluated (91 in azithromycin group and 91 in azithromycin and cefixime group). In azithromycin group 5 (5.4%) patients were culture positive during the follow up visit compared to none in combination (azithromycin and cefixime) group. Four of the five paired isolate belonged to same serotype and genotype indicating that in azithromycin treatment group there was four cases of true treatment failure. Conclusion Single-dose oral azithromycin and cefixime is a better alternative then only azithromycin for treatment of uncomplicated gonococcal urethritis.
Publication Types:
Keywords:
- Azithromycin
- Bangladesh
- Cefixime
- Chlamydia trachomatis
- Gastrointestinal Diseases
- Gonorrhea
- Humans
- Neisseria gonorrhoeae
- Single Person
- Sweden
- Urethritis
- therapy
Other ID:
UI: 102281125
From Meeting Abstracts