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Absolute neutrophil counts (ANC) in HIV-exposed and unexposed infants in Chitungwiza, Zimbabwe.

Wells J, Shetty A, Stranix L, Mateta P, Nyoni N, Chipato T, Maldonado Y; International Conference on AIDS (15th : 2004 : Bangkok, Thailand).

Int Conf AIDS. 2004 Jul 11-16; 15: abstract no. TuPpB2040.

UZ-UCSF Collaborative Research Programme, Harare, Zimbabwe

Background: The evaluation of hematologic abnormalities due to antiretroviral prophylaxis is critical to the success of MTCT clinical trials in Africa. Ethnic neutropenia has been reported in African infants, thereby rendering normal hematologic parameters derived from Caucasian infants inappropriate for grading neutropenia. The aim of this study is to determine if ethnic neutropenia is prevalent in Zimbabwe, and whether intrapartum/neonatal single-dose nevirapine (NVP) has an effect on absolute neutrophil count (ANC). Methods: The study was conducted at two clinics in Zimbabwe. 200 HIV-unexposed and 70 HIV-exposed infants were evaluated at birth, 10 days, 6 weeks, 3 and 4 months of life. All HIV-positive women, and all HIV-exposed infants received single dose NVP. A physical exam and full blood count were performed at each visit. Infants with concurrent viral or bacterial infection were excluded from analysis. Results: The following table illustrates the mean ANC values in Zimbabwean infants (HIV-exposed and un-exposed) and in Caucasian infants (controls). [table: see text]*reference (Oski Textbook of Pediatrics) *reference (Oski Textbook of Pediatrics) Conclusions: Ethnic neutropenia exists in Zimbabwean infants, and should be taken into account during evaluation of low ANC values in HIV-exposed infants receiving NVP prophylaxis. The mean ANC values of HIV-exposed and unexposed infants do not differ significantly. Exposure to NVP prophylaxis does not appear to have an effect on ANC values during early infancy.

Publication Types:
  • Meeting Abstracts
Keywords:
  • AIDS Vaccines
  • Acquired Immunodeficiency Syndrome
  • Africa
  • CD4 Lymphocyte Count
  • Child
  • Female
  • HIV Infections
  • HIV Seropositivity
  • Hematologic Tests
  • Humans
  • Infant
  • Nevirapine
  • Zimbabwe
Other ID:
  • GWAIDS0039186
UI: 102283402

From Meeting Abstracts




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